Publications
Nadres B, Momcilovic M, Shackelford DB, Lisberg A. An Unexpected Partnership: Histone Deacetylase 6 and Glutaminase Inhibition Provide an Opportunity to Overcome Resistance in KRAS and LKB1 Co-mutant Lung Tumors. J Thorac Oncol. 2023 Jul;18(7):847-850. doi: 10.1016/j.jtho.2023.04.012.
Han M, Bushong EA, Segawa M, Tiard A, Wong A, Brady MR, Momcilovic M, Wolf DM, Zhang R, Petcherski A, Madany M, Xu S, Lee JT, Poyurovsky MV, Olszewski K, Holloway T, Gomez A, John MS, Dubinett SM, Koehler CM, Shirihai OS, Stiles L, Lisberg A, Soatto S, Sadeghi S, Ellisman MH, Shackelford DB. Spatial mapping of mitochondrial networks and bioenergetics in lung cancer. Nature. 2023 Mar;615(7953):712-719. doi: 10.1038/s41586-023-05793-3. Epub 2023 Mar 15.
Alhiyari Y, Shao J, Han AY, Miller A, Krane JF, Luff M, Momcilovic M, Shackelford D, Gu Z, John MAS. Modular polymer platform as a novel approach to head and neck cancer therapy. Sci Rep. 2022 Mar 4;12(1):3592. doi: 10.1038/s41598-022-07324-y.
Murray CW, Brady JJ, Han M, Cai H, Tsai MK, Pierce SE, Cheng R, Demeter J, Feldser DM, Jackson PK, Shackelford DB, Winslow MM. LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer. Nat Commun. 2022 Feb 28;13(1):1090. doi: 10.1038/s41467-022-28619-8.
Olszewski K, Barsotti A, Feng XJ, Momcilovic M, Liu KG, Kim JI, Morris K, Lamarque C, Gaffney J, Yu X, Patel JP, Rabinowitz JD, Shackelford DB, Poyurovsky MV. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2022 Mar 17;29(3):423-435.e10. doi: 10.1016/j.chembiol.2021.10.007. Epub 2021 Oct 28.
Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metab. 2021 May 4;33(5):1013-1026.e6. doi: 10.1016/j.cmet.2021.02.001. Epub 2021 Feb 19.
Velez MA, Tsai HHC, Shackelford DB, Garon EB, Lisberg A. What is the current role of immunotherapy in EGFR mutant advanced NSCLC? Lung Cancer. 2022 Apr;166:253-254. doi: 10.1016/j.lungcan.2021.12.001. Epub 2021 Dec 24.
DeNicola GM, Shackelford DB. Metabolic Phenotypes, Dependencies, and Adaptation in Lung Cancer. Cold Spring Harb Perspect Med. 2021 Nov 1;11(11):a037838. doi: 10.1101/cshperspect.a037838.
Mullen PJ, Garcia G Jr, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition. Nat Commun. 2021 Mar 25;12(1):1876. doi: 10.1038/s41467-021-22166-4.
Li R, Salehi-Rad R, Crosson W, Momcilovic M, Lim RJ, Ong SL, Huang ZL, Zhang T, Abascal J, Dumitras C, Jing Z, Park SJ, Krysan K, Shackelford DB, Tran LM, Liu B, Dubinett SM. Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non-Small Cell Lung Cancer. Cancer Res. 2021 Jun 15;81(12):3295-3308. doi: 10.1158/0008-5472.CAN-20-3564. Epub 2021 Apr 14. PMID: 33853830; PMCID: PMC8776246.
Hong A, Piva M, Liu S, Hugo W, Lomeli SH, Zoete V, Randolph CE, Yang Z, Wang Y, Lee JJ, Lo SJ, Sun L, Vega-Crespo A, Garcia AJ, Shackelford DB, Dubinett SM, Scumpia PO, Byrum SD, Tackett AJ, Donahue TR, Michielin O, Holmen SL, Ribas A, Moriceau G, Lo RS. Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity. Cancer Discov. 2021 Mar;11(3):714-735. doi: 10.1158/2159-8290.CD-20-0873. Epub 2020 Dec 14.
Salehi-Rad R, Li R, Tran LM, Lim RJ, Abascal J, Momcilovic M, Park SJ, Ong SL, Shabihkhani M, Huang ZL, Paul M, Shackelford DB, Krysan K, Liu B, Dubinett SM. Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden. Cancer Immunol Immunother. 2021 Aug;70(8):2389-2400. doi: 10.1007/s00262-020-02837-9. Epub 2021 Jan 28.
Riess JW, Frankel P, Shackelford D, Dunphy M, Badawi RD, Nardo L, Cherry SR, Lanza I, Reid J, Gonsalves WI, Kunos C, Gandara DR, Lara PN, Newman E, Paik PK. Phase 1 Trial of MLN0128 (Sapanisertib) and CB-839 HCl (Telaglenastat) in Patients With Advanced NSCLC (NCI 10327): Rationale and Study Design. Clin Lung Cancer. 2021 Jan;22(1):67-70. doi: 10.1016/j.cllc.2020.10.006. Epub 2020 Oct 16.
Hong A, Piva M, Liu S, Hugo W, Lomeli SH, Zoete V, Randolph CE, Yang Z, Wang Y, Lee JJ, Lo SJ, Sun L, Vega-Crespo A, Garcia AJ, Shackelford DB, Dubinett SM, Scumpia PO, Byrum SD, Tackett AJ, Donahue TR, Michielin O, Holmen SL, Ribas A, Moriceau G, Lo RS. Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity. Cancer Discov. 2021 Mar;11(3):714-735. doi: 10.1158/2159-8290.CD-20-0873. Epub 2020 Dec 14.
Segawa M, Wolf DM, Hultgren NW, Williams DS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria. Life Sci Alliance. 2020 Jun 4;3(7):e201900620. doi: 10.26508/lsa.201900620.
Milica Momcilovic, Anthony Jones, Sean T. Bailey, Christopher M. Waldmann, Rui Li, Jason T. Lee, Gihad Abdelhady, Adrian Gomez, Travis Holloway, Ernst Schmid, David Stout, Michael C. Fishbein, Linsey Stiles, Deepa V. Dabir, Steven M. Dubinett, Heather Christofk, Orian Shirihai, Carla M. Koehler, Saman Sadeghi and David B. Shackelford§ (2019) "In vivo imaging of mitochondrial membrane potential in non-small cell lung cancer." Nature 2019 Nov;575(7782):380-384. §corresponding author
Mayuko Segawa, Dane M Wolf , Nan W Hultgren, David S Williams, Alexander M van der Bliek , David B Shackelford , Marc Liesa, Orian S Shirihai. (2020) “Quantification of Cristae Architecture Reveals Time-Dependent Characteristics of Individual Mitochondria” Life Sci Alliance Jun 4;3(7):e201900620.
Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. (2019) “Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent.” EMBO J. 2019 Oct 14:e101056.
Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. (2019) “p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas.” Cell Rep. 2019 Aug 13;28(7):1860-1878.e9. doi: 10.1016/j.celrep.2019.07.027.
Maric T, Mikhaylov G, Khodakivskyi P, Bazhin A, Sinisi R, Bonhoure N, Yevtodiyenko A, Jones A, Muhunthan V, Abdelhady G, Shackelford D, Goun E. (2019) “Bioluminescent-based imaging and quantification of glucose uptake in vivo” Nat Methods. 2019 Jun;16(6):526-532
Milica Momcilovic and David B Shackelford (2019) “Teaching an Old Drug New Tricks” Cancer Cell May 13;35(5):709-711.
Eichner LJ, Brun SN, Herzig S, Young NP, Curtis SD, Shackelford DB, Shokhirev MN, Leblanc M, Vera LI, Hutchins A, Ross DS, Shaw RJ, Svensson RU. (2019) “Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models.” Cell Metab. 2019 Feb 5;29(2):285-302.e7. doi: 10.1016/j.cmet.2018.10.005. Epub 2018 Nov 8.
Claudio R. Scafoglio*, Sean T. Bailey, Gihad Abdelhady, Brendon Villegas, Jie Liu, Jane Yanagawa, Aditya S. Shirali, W. Dean Wallace, Clara E. Magyar, Tristan R. Grogan, David Elashoff, Tonya Walser, Denise R. Aberle, Jorge R. Barrio, Steven M. Dubinett, David B. Shackelford*. “Sodium-Glucose Transporter 2 is a novel diagnostic and therapeutic target for early stage lung adenocarcinoma” (2018) Science Translational Medicine (2018) Sci Transl Med Nov 14; 10(467). *co-corresponding authors
Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR6 Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR. Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. (2018) Cell. 2018 Sep 20;175(1):117-132.e21.
Claudio R. Scafoglio1*, Sean T. Bailey1,2, Gihad Abdelhady1, Brendon Villegas1, Jie Liu3, Jane Yanagawa4, Aditya S. Shirali4, W. Dean Wallace5, Clara E. Magyar5, Tristan R. Grogan6, David Elashoff6, Tonya Walser1, Denise R. Aberle7, Jorge R. Barrio3, Steven M. Dubinett1,3,5,8, David B. Shackelford1* “Sodium-Glucose Transporter 2 is a novel diagnostic and therapeutic target for early stage lung adenocarcinoma” (2018) Science Translational Medicine (in press).
Milica Momcilovic1, Sean T. Bailey1, Jason T. Lee3,11, Michael C. Fishbein2, Daniel Braas3,5, James Go3, Thomas G. Graeber3,4,5, Francesco Parlati12, Susan Demo12, Rui Li1, Tonya C. Walser1, Michael Gricowski13, Robert Shuman13, Julio Ibarra13, Deborah Fridman14, Michael Phelps3,11, Karam Badran6, Maie St. John6, Nicholas Bernthal7, Noah Federman4,9, Jane Yanagawa1,8, Steven M. Dubinett1,2,4, Saman Sadeghi3, Heather Christofk3,4,5,10 and David B. Shackelford1,4§ “The GSK3 signaling axis regulates adaptive glutamine metabolism in lung squamous cell carcinoma.” (2018) Cancer Cell May 14;33(5):905-921.e5. doi: 10.1016/j.ccell.2018.04.002
Milica Momcilovic1, Sean T. Bailey4, Jason T. Lee3, Charles Zamilpa3, Anthony Jones3, Gihad Abdelhady1, James Mansfield5, Kevin P. Francis2, David B. Shackelford1 “Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in Glucose Metabolism in Mouse Models of Lung Cancer” (2018) JoVE (in press).
Christopher M. Waldmann, Adrian Gomez, Phillip Marchis, Sean T. Bailey, Milica Momcilovic, Anthony E. Jones, David B. Shackelford, Saman Sadeghi An Automated Multidose Synthesis of the Potentiometric PET Probe 4-[18F]Fluorobenzyl-Triphenylphosphonium ([18F]FBnTP) (2018) Molecular Imaging and Biology Apr;20(2):205-212. doi: 10.1007/s11307-017-1119-1.
Justin Goodwin, Hyunsung Choi, Meng-hsiung Hsieh, Jorge L. Rivera, Michael L. Nuegent, Jung-MoAhn, Heather N. Hayenga, Pankaj K. Singh, David B. Shackelford, Inkyu Lee, Vladimir Shulaev, Shanta Dhar, Norihiko Takeda, Randall S. Johnson, Jung-whan Kim. Targeting HIF-1α/PDK1 axis by Dichloroacetate 1 (DCA) Suppresses Bleomycin-induced Pulmonary Fibrosis (2018) American Journal of Respiratory Cell and Molecular Biology Feb;58(2):216-231. doi: 10.1165/rcmb.2016-0186OC.
Momcilovic M, Shackelford DB. “Imaging Cancer Metabolism” (2018) Biomol Ther (Seoul). 2018 Jan 1;26(1):81-92. doi: 10.4062/biomolther.2017.220. Review
Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW. “The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.” Nat Commun. 2017 May 26;8:15503. doi: 10.1038/ncomms15503.
Momcilovic M, Shackelford DB. “Dual targeting of EGFR and glutaminase in lung cancer.” Mol Cell Oncol. 2017;5(3):e1297883. Published 2017 Apr 19. doi:10.1080/23723556.2017.1297883
Milica Momcilovic1§, Sean T. Bailey1§, Jason T. Lee3, Michael C. Fishbein2, Clara Magyar2, Daniel Braas3,6, Thomas Graeber3,5,6, Nicholas J. Jackson7, Johannes Czernin3,5, Ethan Emberley8, Matthew Gross8, Julie Janes8, Andy Mackinnon8, Alison Pan8, Mirna Rodriguez8, Melissa Works8, Winter Zhang8, Francesco Parlati8, Susan Demo8, Edward Garon4,5, Kostyantyn Krysan1, Tonya C. Walser1, Steven M. Dubinett1,2,5, Saman Sadeghi3, Heather Christofk3,5,6 and David B. Shackelford1,5* “Targeted Inhibition of EGFR and Glutaminase Inducse Metabolic Crisis in EGFR Mutant Lung Adenocarcinoma.” (2017) Cell Reports Jan 17;18(3):601-610.
Jiang W, Finniss S, Cazacu S, Xiang C, Brodie Z, Mikkelsen T, Poisson L, Shackelford DB, Brodie C “Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma.” Oncotarget. 2016 Jul 29. doi: 10.18632/oncotarget.10919. [Epub ahead of print]
Milica Momcilovic1, Robert McMickle1, Evan Abt1, Atsuko Seki2, Sarah A. Simko1, Clara Magyar2, David B. Stout3, Michael C. Fishbein2, Tonya C. Walser1, Steven M. Dubinett1 and David B. Shackelford1* (2015) “Heightening energetic stress selectively targets LKB1-deficient non-small cell lung cancers.” Cancer Res. 2015 Nov 15;75(22):4910-22. *corresponding author.
Milica Momcilovic1 and David B. Shackelford1** (2015) “Targeting LKB1 in cancer - exposing and exploiting vulnerabilities.” Br J Cancer. 2015 Aug 11;113(4):574-84. doi: 10.1038/bjc.2015.261. Epub 2015 Jul 21. PMID: 26196184
Faubert B, Vincent EE, Griss T, Samborska B, Izreig S, Svensson RU, Mamer OA, Avizonis D, Shackelford DB, Shaw RJ, Jones RG. (2014) Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2554-9. PMID: 24550282
Zadran S, McMickle R, Shackelford D, Kleinman H, Barnhill R, Lugassy C. (2014) Monitoring extra-vascular migratory metastasis (EVMM) of migrating cancer cells using an in vitro co-culture system. Protoc exch. Nov 22, 2013; 2013: 2867. PMID: 24490023
David B. Shackelford (2013) Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor. J Carcinogenesis 2013, 12:16 (8 August 2013). PMID: 24082825
David B. Shackelford*, Evan Abt, Laurie Gerkin, Debbie S. Vasquez, Mathias Leblanc, Atsuko Seki, Liu Wei, Johannes Czernin, Michael C. Fishbein, Paul Mischel and Reuben J. Shaw*. (2013) LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin Cancer Cell 23, 1-16, February 11, 2013. PMID: 23352126; * indicates co-corresponding authors.
Gini B, Zanca C, Guo D, Matsutani T, Masui K, Ikegami S, Yang H, Nathanson D, Villa GR, Shackelford DB, Zhu S, Tanaka K, Babic I, Akhavan D, Lin K, Assuncao A, Gu Y, Bonetti B, Mortensen DS, Xu S, Raymon HK, Cavenee WK, Furnari FB, James CD, Kroemer G, Heath JR, Hege K, Chopra R, Cloughesy TF, Mischel PS. (2013) The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas. Clin Cancer Res. 2013 Oct 15;19(20):5722-32. doi: 10.1158/1078-0432.CCR-13-0527. Epub 2013 Sep 12. PMID: 24030701
Wei W, Shi Q, Remacle F, Qin L, Shackelford DB, Shin YS, Mischel PS, Levine RD, Heath JR. (2013) Hypoxia induces a phase transition within a kinase signaling network in cancer cells. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1352-60. doi: 10.1073/pnas.1303060110. Epub 2013 Mar 25. PMID: 23530221
